Association Between Common Variants Near the Melanocortin 4 Receptor Gene and Severe Antipsychotic Drug–Induced Weight Gain
نویسندگان
چکیده
منابع مشابه
Association between the Melanocortin-4 Receptor (MC4R) Gene Polymorphisms and Growth Trait in Sumba Ongole Cattle
Melanocortin-4 receptor (MC4R) gene has been known as a candidate gene for growth traits in livestock. This research was aimed to identify the polymorphism of MC4R gene and its association with growth traits in Sumba Ongole (SO) cattle. The growth traits data consist of body weight and body size. Eighty four blood samples were collected and used for DNA isolation. The...
متن کاملRole of 5-HT2C receptor gene variants in antipsychotic-induced weight gain
Antipsychotic-induced weight gain is a serious side effect of antipsychotic medication that can lead to increased morbidity, mortality, and non-compliance in patients. Numerous single nucleotide polymorphisms have been studied for association with antipsychotic-induced weight gain in an attempt to find genetic predictors of this side effect. An ability to predict this side effect could lead to ...
متن کاملDo common variants separate between obese melanocortin-4 receptor gene mutation carriers and non-carriers? The impact of cryptic relatedness.
BACKGROUND/AIMS Genome-wide association studies revealed associations of single nucleotide polymorphisms (SNPs) flanking MC4R with body mass index variability and obesity. We genotyped 28 SNPs, covering MC4R, and searched for haplotypes discriminating between obese mutation carriers and non-carriers. METHODS We analyzed all three-marker haplotype combinations of the 28 SNPs to discriminate be...
متن کاملLack of Association between Somatotropin Receptor Gene Polymorphism and Birth Weight of Iranian Indigenous Sistani Cattle
The objective of the present study was to determine polymorphism within the promoter region of somatotropin receptor genes in indigenous Sistani cattle (Bos indicus) and associations between this polymorphism and breeding value of birth weight. The pedigree structure was included by considering 1173 animals with 600 progeny birth weight data obtained from a Zhark breeding station in Sistan and ...
متن کاملA comprehensive analysis of mitochondrial genes variants and their association with antipsychotic-induced weight gain.
Antipsychotic Induced Weight Gain (AIWG) is a common and severe side effect of many antipsychotic medications. Mitochondria play a vital role for whole-body energy homeostasis and there is increasing evidence that antipsychotics modulate mitochondrial function. This study aimed to examine the role of variants in nuclear-encoded mitochondrial genes and the mitochondrial DNA (mtDNA) in conferring...
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ژورنال
عنوان ژورنال: Archives of General Psychiatry
سال: 2012
ISSN: 0003-990X
DOI: 10.1001/archgenpsychiatry.2012.191